Since 2006, scientists around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome.
Settings
Save and close
Since 2006, scientists around the world have been working together to generate a targeted knockout mutation for every gene in the mouse genome.
Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016. The National Institutes of Health has funded three “KOMP2” centers in the United States, including one at The Jackson Laboratory, to work together on the immense task of producing and phenotyping these mice. We are pleased to contribute to this international effort establishing a global resource of knockout mice and related database of gene function.
The KOMP program's first phase focused on creating targeted knockout mutations in mouse ES cells, while the second phase, KOMP2, aims to generate knockout mouse strains from these cells. The JAX KOMP2 Production Center will leverage The Jackson Laboratory's extensive experience to produce germline-competent chimeras and mouse cohorts, ensuring genetic quality and viability.
View moreBroad phenotypic characterization of emerging mouse models enhances their utility to the scientific community, particularly through the KOMP program's library of single-gene knockout strains. Effective high-throughput phenotyping is crucial for understanding genotype/phenotype relationships, and the Jackson Laboratory KOMP Phenotyping Center offers a robust pipeline to assess the effects of gene elimination.
View more